Lookup NU author(s): Dr Kamilla Mahkamova,
Dr Annette Meeson
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Hypoxic stress in a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem-cell properties. Hypoxia inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expressed in thyroid cancers. There is growing evidence that the HIF pathway plays a significant role in the maintenance of thyroid cancer stem cells (CSC). We have isolated thyroid CSC from a papillary thyroid cancer derived cell line (BCPAP) and an anaplastic thyroid cancer derived cell line (SW1736) as Side population (SP) cells (a putative stem cell population) and treated them with cobalt chloride (II) to induce hypoxia. We observed an increase in the SP population of cells within the thyroid cancer cell lines following induction of hypoxia.
Author(s): Mahkamova K, Latar N, Aspinall S, Meeson A
Publication type: Article
Publication status: Published
Journal: World Journal of Surgery
Print publication date: 01/02/2018
Online publication date: 22/11/2017
Acceptance date: 13/10/2017
Date deposited: 10/11/2017
ISSN (print): 0364-2313
ISSN (electronic): 1432-2323
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