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Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples

Lookup NU author(s): Dr Olivier Govaere

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2016 The Authors. This data set is composed of transcriptomics analyses of (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (ALF) and (ii) hepatic cell systems exposed to acetaminophen and their respective controls. The in vitro systems include widely employed cell lines i.e. HepaRG and HepG2 cells as well as a novel stem cell-derived model i.e. human skin-precursors-derived hepatocyte-like cells (hSKP-HPC). Data from primary human hepatocytes was also added to the data set "Open TG-GATEs: a large-scale toxicogenomics database" (Igarashi et al., 2015) [1]. Changes in gene expression due to acetaminophen intoxication as well as comparative information between human in vivo and in vitro samples are provided. The microarray data have been deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GEO: GSE74000. The provided data is used to evaluate the predictive capacity of each hepatic in vitro system and can be directly compared with large-scale publically available toxicogenomics databases. Further interpretation and discussion of these data feature in the corresponding research article "Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems" (Rodrigues et al., 2016) [2].


Publication metadata

Author(s): Rodrigues RM, Govaere O, Roskams T, Vanhaecke T, Rogiers V, De Kock J

Publication type: Article

Publication status: Published

Journal: Data in Brief

Year: 2016

Volume: 7

Pages: 1052-1057

Print publication date: 01/06/2016

Online publication date: 26/03/2016

Acceptance date: 18/03/2017

Date deposited: 08/12/2017

ISSN (electronic): 2352-3409

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.dib.2016.03.069

DOI: 10.1016/j.dib.2016.03.069


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