Lookup NU author(s): Dr Olivier Govaere
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© 2015 Elsevier Inc.Different approaches predict the outcome for patients with hepatocellular carcinoma (HCC). The expression of biliary-hepatic progenitor cell markers generally correlates with poor prognosis. This article focuses on the pathogenesis of HCC, how differentiation or dedifferentiation leads to a phenotype switch, and heterogeneity in the same tumor. A tumor cell decides its fate based on a complex interplay of signaling pathways. Interaction with the microenvironment decides whether it will invade, proliferate, or enter survival mode. Several signaling pathways contribute to stemness features, reflecting a small chemoresistant subpopulation of the tumor that expresses biliary-hepatic progenitor cell markers.
Author(s): Govaere O, Roskams T
Publication type: Review
Publication status: Published
Journal: Clinics in Liver Disease
Print publication date: 01/05/2015
Online publication date: 03/03/2015
Acceptance date: 01/01/1900
ISSN (print): 1089-3261
ISSN (electronic): 1557-8224
Publisher: W.B. Saunders
PubMed id: 25921662