Lookup NU author(s): Dr Caroline Wilson,
Professor Derek Mann,
Dr Lee Borthwick
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 The Authors Novel insights into the epigenetic control of chronic liver diseases are now emerging. Recent advances in our understanding of the critical roles of DNA methylation, histone modifications and ncRNA may now be exploited to improve management of fibrosis/cirrhosis and cancer. Furthermore, improved technologies for the detection of epigenetic markers from patients' blood and tissues will vastly improve diagnosis, treatment options and prognostic tracking. The aim of this review is to present recent findings from the field of liver epigenetics and to explore their potential for translation into therapeutics to prevent disease promoting epigenome reprogramming and reverse epigenetic changes.
Author(s): Wilson CL, Mann DA, Borthwick LA
Publication type: Review
Publication status: Published
Journal: Advanced Drug Delivery Reviews
Print publication date: 01/11/2017
Online publication date: 25/10/2017
Acceptance date: 17/10/2017
ISSN (print): 0169-409X
ISSN (electronic): 1872-8294
Publisher: Elsevier B.V.