Lookup NU author(s): Professor William Willats
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© 2017 American Chemical Society. The synthesis of linear and (1 → 6)-branched β-(1 → 3)-d-galactans, structures found in plant arabinogalactan proteins (AGPs), is described. The synthetic strategy relies on iterative couplings of monosaccharide and disaccharide thioglycoside donors, followed by a late-stage glycosylation of heptagalactan backbone acceptors to introduce branching. A key finding from the synthetic study was the need to match protective groups in order to tune reactivity and ensure selectivity during the assembly. Carbohydrate microarrays were generated to enable the detailed epitope mapping of two monoclonal antibodies known to recognize AGPs: JIM16 and JIM133.
Author(s): Andersen MCF, Boos I, Ruprecht C, Willats WGT, Pfrengle F, Clausen MH
Publication type: Article
Publication status: Published
Journal: Journal of Organic Chemistry
Print publication date: 01/12/2017
Online publication date: 09/11/2017
Acceptance date: 19/07/2017
ISSN (print): 0022-3263
ISSN (electronic): 1520-6904
Publisher: American Chemical Society
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