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Epigenetics in Parkinson’s Disease

Lookup NU author(s): Professor Tiago Outeiro

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Abstract

© 2017, Springer International Publishing AG. Parkinson’s disease (PD) is a highly complex neurodegenerative disorder with a multifactorial origin. Although several cellular mechanisms and genes have been implicated in the onset and progression of the disease, the precise molecular underpinnings of the disease remain unclear. In this context, epigenetic modulation of gene expression by environmental factors is emerging as an important mechanism in PD and in other neurodegenerative disorders. Thus, epigenetic mechanisms, such as DNA methylation, histone modifications and altered microRNA expression, have been under intense investigation due to their possible involvement in PD. Epigenetic modulation is responsible for inducing differential gene expression, a phenomenon which is essential throughout life in order to regulate multiple cellular responses such as development, cellular fate commitment and adaptation to the environment. Disturbances of a balanced gene expression can, therefore, have detrimental effects. Environmental factors can challenge the establishment and maintenance of epigenetic modifications and could thereby fill the gap in our further understanding of origin and/or progression of neurodegenerative diseases. In this chapter, we focus on the role of epigenetics in PD.


Publication metadata

Author(s): Pavlou MAS, Outeiro TF

Editor(s): Raul Delgado-Morales

Publication type: Book Chapter

Publication status: Published

Book Title: Neuroepigenomics in Aging and Disease

Year: 2017

Volume: 978

Pages: 363-390

Online publication date: 19/05/2017

Acceptance date: 02/04/2016

Series Title: Advances in Experimental Medicine and Biology

Publisher: Springer

Place Published: New York

URL: https://doi.org/10.1007/978-3-319-53889-1_19

DOI: 10.1007/978-3-319-53889-1_19

PubMed id: 28523556

Library holdings: Search Newcastle University Library for this item

ISBN: 9783319538891


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