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Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina

Lookup NU author(s): Dr Vidhyasankar Krishnamoorthy



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Standard models of stimulus encoding in the retina postulate that image presentations activate neurons according to the increase of preferred contrast inside the receptive field. During natural vision, however, images do not arrive in isolation, but follow each other rapidly, separated by sudden gaze shifts. We here report that, contrary to standard models, specific ganglion cells in mouse retina are suppressed after a rapid image transition by changes in visual patterns across the transition, but respond with a distinct spike burst when the same pattern reappears. This sensitivity to image recurrence depends on opposing effects of glycinergic and GABAergic inhibition and can be explained by a circuit of local serial inhibition. Rapid image transitions thus trigger a mode of operation that differs from the processing of simpler stimuli and allows the retina to tag particular image parts or to detect transition types that lead to recurring stimulus patterns.

Publication metadata

Author(s): Krishnamoorthy V, Weick M, Gollisch T

Publication type: Article

Publication status: Published

Journal: eLife

Year: 2017

Volume: 6

Online publication date: 06/03/2017

Acceptance date: 20/02/2017

Date deposited: 21/12/2017

ISSN (electronic): 2050-084X

Publisher: eLife Sciences Publications


DOI: 10.7554/eLife.22431

PubMed id: 28747662


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