Lookup NU author(s): Professor Tiago Outeiro
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Phosphorylation of α-synuclein (aSyn) on serine 129 is one of the major post-translation modifications found in Lewy bodies, the typical pathological hallmark of Parkinson's disease. Here, we found that both PLK2 and PLK3 phosphorylate aSyn on serine 129 in yeast. However, only PLK2 increased aSyn cytotoxicity and the percentage of cells presenting cytoplasmic foci. Consistently, in mammalian cells, PLK2 induced aSyn phosphorylation on serine 129 and induced an increase in the size of the inclusions. Our study supports a role for PLK2 in the generation of aSyn inclusions by a mechanism that does not depend directly on serine 129 phosphorylation. © 2013 Springer Science+Business Media New York.
Author(s): Basso E, Antas P, Marijanovic Z, Goncalves S, Tenreiro S, Outeiro TF
Publication type: Review
Publication status: Published
Journal: Molecular Neurobiology
Print publication date: 01/12/2013
Online publication date: 17/05/2013
ISSN (print): 0893-7648
ISSN (electronic): 1559-1182
PubMed id: 23677647