Lookup NU author(s): Dr Khimara Naidoo,
Professor Mark Birch-Machin
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley , 2018.
For re-use rights please refer to the publisher's terms and conditions.
Skin ageing is a complex process involving both internal and external factors, which leads to a progressive loss of cutaneous function and structure. Solar radiation is the primary environmental factor implicated in the development of skin ageing and the term photoageing describes the distinct clinical, histological and structural features of chronically sun-exposed skin. The changes that accompany photoageing are undesirable for aesthetic reasons and can compromise the skin and make it more susceptible to a number of dermatological disorders. As a result, skin ageing is a now topic that is of growing interest and concern to the general population, illustrated by the increased demand for effective interventions that can prevent or ameliorate the clinical changes associated with aged skin. In this viewpoint essay we explore the role that mitochondria play in the process of skin photoageing. There is continuing evidence supporting the proposal that mitochondria dysfunction and oxidative stress are important contributing factors in the development of skin photoageing. Further skin-directed mitochondrial research is warranted to fully understand the impact of mitochondrial status and function in skin health. A greater understanding of the ageing process and the regulatory mechanisms involved could lead to the development of novel preventative andtherapeutic interventions for skin ageing.
Author(s): Naidoo K, Hanna R, Birch-Machin MA
Publication type: Article
Publication status: Published
Journal: Experimental Dermatology
Print publication date: 01/02/2018
Online publication date: 02/12/2017
Acceptance date: 23/11/2017
Date deposited: 22/12/2017
ISSN (print): 0906-6705
ISSN (electronic): 1600-0625
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