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What is the role of mitochondrial dysfunction in skin photoaging?

Lookup NU author(s): Dr Khimara Naidoo, Rebecca Hanna, Professor Mark Birch-Machin

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley , 2018.

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Abstract

Skin ageing is a complex process involving both internal and external factors, which leads to a progressive loss of cutaneous function and structure. Solar radiation is the primary environmental factor implicated in the development of skin ageing and the term photoageing describes the distinct clinical, histological and structural features of chronically sun-exposed skin. The changes that accompany photoageing are undesirable for aesthetic reasons and can compromise the skin and make it more susceptible to a number of dermatological disorders. As a result, skin ageing is a now topic that is of growing interest and concern to the general population, illustrated by the increased demand for effective interventions that can prevent or ameliorate the clinical changes associated with aged skin. In this viewpoint essay we explore the role that mitochondria play in the process of skin photoageing. There is continuing evidence supporting the proposal that mitochondria dysfunction and oxidative stress are important contributing factors in the development of skin photoageing. Further skin-directed mitochondrial research is warranted to fully understand the impact of mitochondrial status and function in skin health. A greater understanding of the ageing process and the regulatory mechanisms involved could lead to the development of novel preventative andtherapeutic interventions for skin ageing.


Publication metadata

Author(s): Naidoo K, Hanna R, Birch-Machin MA

Publication type: Article

Publication status: Published

Journal: Experimental Dermatology

Year: 2018

Volume: 27

Issue: 2

Pages: 124-128

Print publication date: 01/02/2018

Online publication date: 02/12/2017

Acceptance date: 23/11/2017

Date deposited: 22/12/2017

ISSN (print): 0906-6705

ISSN (electronic): 1600-0625

Publisher: Wiley

URL: https://doi.org/10.1111/exd.13476

DOI: 10.1111/exd.13476


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