Toggle Main Menu Toggle Search

Open Access padlockePrints

Atrial arrhythmia after transcatheter closure of secundum atrial septal defects in patients ≥40 years of age

Lookup NU author(s): Dr Lee Ferguson, Dr Stephen Lord, Dr Ewen Shepherd, Dr John Bourke, Dr David Crossland, Dr John O'Sullivan

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

© 2017 The Author. European Society of Cardiology. All rights reserved. Aim Data on arrhythmia outcome following device closure of atrial septal defect (ASD) are lacking. This study provides medium- term follow-up data on atrial arrhythmias in patients who were ≥40 years of age at the time of transcatheter ASD closure. Methods and results It is a retrospective review. Mean age of the 159 patients was 57 years. Median follow-up was 3.6 years (range 6 months-10.9 years). Patients were classified, according to arrhythmia status prior to ASD closure, into Group I, no history of atrial arrhythmia (n = 119, mean age 55.5 years); Group II, paroxysmal atrial arrhythmia (n = 18, mean age 55.7 years); and Group III, persistent atrial fibrillation (n = 22, mean age 65.7 years). Group III patients were significantly older, had larger left atrial size, and had higher mean pulmonary arterial pressure than Group I and II patients (P < 0.001). Prior to closure, radiofrequency ablation was carried out in 12/18 (66%) of Group II and 3/22 (14%) of Group III. After device closure, 7 patients (6%) of Group I developed new atrial fibrillation. Fifty per cent (9/18) of Group II but only 9% (2/22) of Group III were in sinus rhythm on follow-up. Conclusion Device closure alone in patients with persistent atrial arrhythmia is not likely to restore sinus rhythm in the medium term. New atrial arrhythmia occurred in 6% of patients who were in sinus rhythm prior to device closure. At least 50% of the patients with paroxysmal atrial arrhythmia continue to have significant atrial arrhythmia following device closure, and the role of ablation prior to closure in patients with a history of arrhythmia requires refinement.


Publication metadata

Author(s): Duong P, Ferguson LP, Lord S, Murray S, Shepherd E, Bourke JP, Crossland D, O'Sullivan J

Publication type: Article

Publication status: Published

Journal: EP Europace

Year: 2017

Volume: 19

Issue: 8

Pages: 1322-1326

Print publication date: 01/08/2017

Online publication date: 04/10/2016

Acceptance date: 29/05/2016

ISSN (print): 1099-5129

ISSN (electronic): 1532-2092

Publisher: Oxford University Press

URL: https://doi.org/10.1093/europace/euw186

DOI: 10.1093/europace/euw186


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share