Toggle Main Menu Toggle Search

ePrints

Decreased male reproductive success in association with mitochondrial dysfunction

Lookup NU author(s): Dr Mika Martikainen, Dr John Grady, Dr Yi Ng, Dr Charlotte Alston, Dr Grainne Gorman, Professor Robert Taylor, Professor Bobby McFarland, Professor Doug Turnbull

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

The reproductive success of men with mitochondrial disease is to date unreported. We compared the age- and era-adjusted reproductive success of 94 British male patients with mitochondrial disease to that of the UK general male population. The reproductive success of men with mitochondrial disease was 65% of that in the general population (95% confidence interval: 53%; 79%), and the effect magnitude was related to the disease severity. This contrasts with the two previous studies finding that the reproductive success of women with mitochondrial DNA disease is not impaired. We conclude that the reproductive health of men with mitochondrial disease merits increased clinical attention.


Publication metadata

Author(s): Martikainen MH, Grady JP, Ng YS, Alston CL, Gorman GS, Taylor RW, McFarland R, Turnbull DM

Publication type: Article

Publication status: Published

Journal: European Journal of Human Genetics

Year: 2017

Volume: 25

Issue: 10

Pages: 1162-1164

Online publication date: 16/08/2017

Acceptance date: 20/06/2017

ISSN (print): 1018-4813

ISSN (electronic): 1476-5438

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/ejhg.2017.114

DOI: 10.1038/ejhg.2017.114

PubMed id: 28812649


Altmetrics

Altmetrics provided by Altmetric


Actions

    Link to this publication


Share