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Lookup NU author(s): Dr Zafer Tandogdu
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© 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Objectives: To assess Asian data from Global Prevalence Study on Infections in Urology (GPIU study) which has been performed more than 10 years. Methods: Seventeen Asian countries participated in the GPIU study between 2004 and 2013. Data for these countries were collected from the web-based GPIU database. The point prevalence of urinary tract infections (UTI) and antimicrobial susceptibility of representative pathogens were analysed for Asian geographic regions. Results: A total of 6706 patients (5271 male, 1435 female) were assessed during the study period, and 659 patients were diagnosed with a UTI (9.8%). Of these UTI patients, 436 were male and 223 were female. Mean patient age was 54.9 ± 19.3 years. Pyelonephritis and cystitis were the most common clinical diagnoses, representing 30.7% and 29.9% of patients, respectively. Escherichia coli was the most frequently identified uropathogen (38.7%). For the patients with urinary tract infection, cephalosporins were the most frequently used antibiotics (34.4%), followed by fluoroquinolones (24.1%), aminoglycosides (16.8%). Fluoroquinolone resistance was relatively high (ciprofloxacin 54.9%, levofloxacin 39.0%), and cephalosporin resistance 42% (42.5-49.4%). Of the antibiotics evaluated, uropathogens had maintained the highest level of susceptibility to amikacin and imipenem (24.9% and 11.3% resistance rates, respectively). Conclusion: Uropathogens in many Asian countries had high resistance to broad-spectrum antibiotics. Knowledge of regional and local resistance data and prudent use of antibiotics are important for proper management of UTI in Asian countries.
Author(s): Choe H-S, Lee S-J, Cho Y-H, Cek M, Tandogdu Z, Wagenlehner F, Bjerklund-Johansen TE, Naber K
Publication type: Article
Publication status: Published
Journal: Journal of Infection and Chemotherapy
Year: 2018
Volume: 24
Issue: 4
Pages: 278-283
Print publication date: 01/04/2018
Online publication date: 29/11/2017
Acceptance date: 30/11/2017
ISSN (print): 1341-321X
ISSN (electronic): 1437-7780
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.jiac.2017.11.013
DOI: 10.1016/j.jiac.2017.11.013
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