Lookup NU author(s): Dr Agnieszka Pazderska,
Dr Stephen Ball,
Dr Timothy Cheetham,
Dr Richard Quinton
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© 2018 The authors Published by Bioscientifica Ltd. We present herein our 20-year experience of pubertal induction in apubertal older (median age 56 years; range 38.4–69.5) men with congenital hypogonadotrophic hypogonadism (n = 7) using a simple fixed-dose and fixed-interval intramuscular testosterone that we originally pioneered in relation to achieving virilisation of natal female transgender men. This regime was effective and well tolerated, resulting in complete virilisation by around 1 year after treatment initiation. No physical or psychological adverse effects were encountered in this group of potentially vulnerable individuals. There were no abnormal excursions of laboratory parameters and extended follow-up beyond the first year of treatment revealed remarkable improvements in bone density. We highlight advantages to both patients and physicians of this regime in testosterone-naïve older men with congenital hypogonadism and discourage the over-rigid application to such patients of treatment algorithms derived from paediatric practice in relation to the evaluation and management in younger teenagers with delayed puberty of uncertain cause.
Author(s): Pazderska A, Mamoojee Y, Artham S, Miller M, Ball SG, Cheetham T, Quinton R
Publication type: Article
Publication status: Published
Journal: Endocrine Connections
Print publication date: 01/01/2018
Acceptance date: 27/11/2017
Date deposited: 22/01/2018
ISSN (electronic): 2049-3614
Publisher: BioScientifica Ltd
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