Lookup NU author(s): Professor Rick Lewis
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© 2018 Elsevier GmbH. Lipoproteins are attached to the outer leaflet of the membrane by a di- or tri-acylglyceryl moiety and are thus positioned in the membrane-cell wall interface. Consequently, lipoproteins are involved in many surface associated functions, including cell wall synthesis, electron transport, uptake of nutrients, surface stress response, signal transduction, and they represent a reservoir of bacterial virulence factors. Inspection of 123 annotated Staphylococcus aureus genome sequences in the public domain revealed that this organism devotes about 2-3% of its coding capacity to lipoproteins, corresponding to about 70 lipoproteins per genome. 60 of these lipoproteins were identified in 95% of the genomes analyzed, which thus constitute the core lipoproteome of S. aureus. 30% of the conserved staphylococcal lipoproteins are substrate-binding proteins of ABC transporters with roles in nutrient transport. With a few exceptions, much less is known about the function of the remaining lipoproteins, representing a large gap in our knowledge of this functionally important group of proteins. Here, we summarize current knowledge, and integrate information from genetic context analysis, expression and regulatory data, domain architecture, sequence and structural information, and phylogenetic distribution to provide potential starting points for experimental evaluation of the biological function of the poorly or uncharacterized lipoproteome of S. aureus.
Author(s): Graf A, Lewis RJ, Fuchs S, Pagels M, Engelmann S, Riedel K, Pane-Farre J
Publication type: Article
Publication status: Published
Journal: International Journal of Medical Microbiology
Print publication date: 01/08/2018
Online publication date: 01/02/2018
Acceptance date: 27/01/2018
ISSN (print): 1438-4221
ISSN (electronic): 1618-0607
Publisher: Elsevier GmbH - Urban und Fischer
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