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Long-term exposure to road traffic noise, ambient air pollution, and cardiovascular risk factors in the HUNT and lifelines cohorts

Lookup NU author(s): Professor Paul Burton

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Oxford University Press, 2017.

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Abstract

© The Author 2016. Aims Blood biochemistry may provide information on associations between road traffic noise, air pollution, and cardiovascular disease risk. We evaluated this in two large European cohorts (HUNT3, Lifelines). Methods and results Road traffic noise exposure was modelled for 2009 using a simplified version of the Common Noise Assessment Methods in Europe (CNOSSOS-EU). Annual ambient air pollution (PM10, NO2) at residence was estimated for 2007 using a Land Use Regression model. The statistical platform DataSHIELD was used to pool data from 144 082 participants aged ≥20 years to enable individual-level analysis. Generalized linear models were fitted to assess cross-sectional associations between pollutants and high-sensitivity C-reactive protein (hsCRP), blood lipids and for (Lifelines only) fasting blood glucose, for samples taken during recruitment in 2006-2013. Pooling both cohorts, an inter-quartile range (IQR) higher day-time noise (5.1 dB(A)) was associated with 1.1% [95% confidence interval (95% CI: 0.02-2.2%)] higher hsCRP, 0.7% (95% CI: 0.3-1.1%) higher triglycerides, and 0.5% (95% CI: 0.3-0.7%) higher high-density lipoprotein (HDL); only the association with HDL was robust to adjustment for air pollution. An IQR higher PM10 (2.0 mg/m3) or NO2 (7.4 mg/m3) was associated with higher triglycerides (1.9%, 95% CI: 1.5- 2.4% and 2.2%, 95% CI: 1.6-2.7%), independent of adjustment for noise. Additionally for NO2, a significant association with hsCRP (1.9%, 95% CI: 0.5-3.3%) was seen. In Lifelines, an IQR higher noise (4.2 dB(A)) and PM10 (2.4 mg/ m3) was associated with 0.2% (95% CI: 0.1-0.3%) and 0.6% (95% CI: 0.4-0.7%) higher fasting glucose respectively, with both remaining robust to adjustment for air/noise pollution. Conclusion Long-term exposures to road traffic noise and ambient air pollution were associated with blood biochemistry, providing a possible link between road traffic noise/air pollution and cardio-metabolic disease risk.


Publication metadata

Author(s): Cai Y, Hansell AL, Blangiardo M, Burton PR, De Hoogh K, Doiron D, Fortier I, Gulliver J, Hveem K, Mbatchou S, Morley DW, Stolk RP, Zijlema WL, Elliott P, Hodgson S

Publication type: Article

Publication status: Published

Journal: European Heart Journal

Year: 2017

Volume: 38

Issue: 29

Pages: 2290-2296

Online publication date: 31/05/2017

Acceptance date: 28/04/2017

Date deposited: 28/03/2019

ISSN (print): 0195-668X

ISSN (electronic): 1522-9645

Publisher: Oxford University Press

URL: https://doi.org/10.1093/eurheartj/ehx263

DOI: 10.1093/eurheartj/ehx263


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