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A Genetically Selected Cyclic Peptide Inhibitor of BCL6 Homodimerization

Lookup NU author(s): Professor Mike Waring

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Abstract

We report an inhibitor of the homodimeric protein-protein interaction of the BCL6 oncoprotein, identified from a genetically encoded SICLOPPS library of 3.2 million cyclic hexpeptides in combination with a bacterial reverse two-hybrid system. This cyclic peptide is shown to bind the BTB domain of BCL6, disrupts its homodimerization, and subsequent binding of the SMRT2 corepressor peptide.

Publication metadata

Author(s): Osher EL, Castillo F, Elumalai N, Waring MJ, Pairaudeau G, Tavassoli A

Publication type: Article

Publication status: Published

Journal: Bioorganic & Medicinal Chemistry

Year: 2018

Volume: 26

Issue: 11

Pages: 3034-3038

Print publication date: 15/07/2018

Online publication date: 09/03/2018

Acceptance date: 07/03/2018

Date deposited: 15/03/2018

ISSN (print): 0968-0896

ISSN (electronic): 1464-3391

Publisher: Pergamon Press

URL: https://doi.org/10.1016/j.bmc.2018.03.012

DOI: 10.1016/j.bmc.2018.03.012

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