Lookup NU author(s): Dr Dina Tiniakos Tiniakos
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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Staging of fibrosis in medical liver biopsies has inherent interobserver variability. There are a number of disease-specific scoring systems available. While recognising the importance of these scoring systems, there is scope to consider how concordance amongst histopathologists could be improved using a generic fibrosis staging system.Using virtual slides, we approached both specialist liver histopathologists and general histopathologists from the UK to assess the degree of fibrosis against a proposed four-tiered reporting system. Example reference images were then produced and distributed to the same responders who were asked to rate a second set of slides to assess if the use of reference images improved concordance between pathologists.The use of reference images eliminated spread across three categories (from 15% to 0%). Overall, agreement was already good; our study showed an improved agreement amongst all participants for percentage agreement (67.79% to 70.08%) and interobserver agreement improved (Fleiss' Kappa 0.55 to 0.59).
Author(s): German AL, Fleming K, Kaye P, Davies S, Goldin R, Hubscher SG, Tiniakos D, McGregor A, Wyatt JI
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Pathology
Print publication date: 01/04/2018
Online publication date: 10/11/2017
Acceptance date: 31/10/2017
ISSN (print): 0021-9746
ISSN (electronic): 1472-4146
Publisher: BMJ Group
PubMed id: 29127142
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