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Lookup NU author(s): Professor Azfar Zaman
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© 2018, Royal College of Physicians of Edinburgh. All rights reserved. ORBITA was a placebo-controlled, multicentre, randomised trial of percutaneous coronary intervention (PCI) conducted in the UK. It enrolled patients with stable angina or equivalent symptoms and at least one angiographically severe lesion ≥ 70% in at least one vessel and vulnerable to PCI. Notable exclusions were patients admitted with an acute coronary syndrome, previous coronary artery bypass surgery and presence of disease in the left main stem. After enrolment there were two distinct phases to the trial that differentiated it from previous PCI trials. For the fi rst 6 weeks all patients underwent an intensive medical optimisation phase during which antianginal therapy was titrated. All patients had (telephone) access to a study doctor who was responsible for optimising therapy based on patient history. The second phase, after this 6 week period, was a pre-randomisation assessment followed by the randomised (wire across lesion only vs. PCI) blinded procedure with both groups being treated with identical duration of dual antiplatelet therapy. During the intervention procedure, patients had auditory isolation with headphones playing music throughout. The outcome measures were angina (measured using Seattle Angina Questionnaire), quality of life (quantifi ed using the 5 level EuroQol 5 dimensions), functional capacity using cardiopulmonary exercise testing and myocardial ischaemic burden with dobutamine stress echocardiography. Importantly, the clinical team including all staff present at the randomised blinded procedure were blinded to the results of the symptom burden and quality of life assessments.
Author(s): Zaman AG
Publication type: Article
Publication status: Published
Journal: Journal of the Royal College of Physicians of Edinburgh
Year: 2018
Volume: 48
Issue: 1
Pages: 40-43
Print publication date: 01/03/2018
Acceptance date: 01/01/1900
ISSN (print): prin-t
Publisher: Royal College of Physicians of Edinburgh
URL: https://doi.org/10.4997/JRCPE.2018.109
DOI: 10.4997/JRCPE.2018.109
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