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Simplifying [¹⁸F]GE-179 PET: are both arterial blood sampling and 90-minute acquisitions essential?

Lookup NU author(s): Professor David BrooksORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Introduction The NMDA receptor radiotracer [18F]GE-179 has been used with 90-minute scans and arterial plasma input functions. We explored whether 1) arterial blood sampling is avoidable; and 2) shorter scans are feasible. Methods For 20 existing [18F]GE-179 datasets we generated: 1) standardised uptake values (SUVs) over eight intervals; 2) volume of distribution (VT) images using population-based input functions (PBIFs), scaled using one parent plasma sample; 3) VT images using three shortened datasets, using the original parent plasma input functions (ppIFs)Results Correlations with the original ppIF-derived 90-minute VTs increased for later interval SUVs (maximal ρ=0.78; 80–90 minutes). They were strong for PBIF-derived VTs (ρ=0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80 minute original ppIF-derived VTs (ρ=0.97–1.00), which suffered regionally variant negative bias. Conclusions Where arterial blood sampling is available, reduction of scan duration to 60 minutes is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived VTs.

Publication metadata

Author(s): McGinnity CJ, Riaño Barros DA, Trigg W, Brooks DJ, Hinz R, Duncan J, Koepp MJ, Hammers A

Publication type: Article

Publication status: Published

Journal: EJNMMI Research

Year: 2018

Volume: 8

Online publication date: 11/06/2018

Acceptance date: 08/05/2018

Date deposited: 09/05/2018

ISSN (electronic): 2191-219X

Publisher: SpringerOpen

URL: https://doi.org/10.1186/s13550-018-0396-2

DOI: 10.1186/s13550-018-0396-2

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