Lookup NU author(s): Professor Konstantinos Stellos
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© 2017 Elsevier Inc. Epidemiological studies have shown that ageing is a major non-reversible risk factor for cardiovascular disease. Vascular ageing starts early in life and is characterized by a gradual change of vascular structure and function resulting in increased arterial stiffening. At the present review we discuss the role of the most important molecular pathways involved in vascular ageing, their association with arterial stiffening and possible novel therapeutic targets that may delay this otherwise irreversible degenerating process. Specifically, we discuss the role of oxidative stress, telomere shortening, and ubiquitin proteasome system in endothelial cell senescence and dysfunction in vascular inflammation and in arterial stiffening. Further, we summarize the most important molecular mechanisms regulating vascular ageing including sirtuin 1, telomerase, klotho, JunD, and amyloid beta 1-40 peptide.
Author(s): Laina A, Stellos K, Stamatelopoulos K
Publication type: Article
Publication status: Published
Journal: Experimental Gerontology
Print publication date: 01/08/2018
Online publication date: 15/06/2017
Acceptance date: 12/06/2017
ISSN (print): 0531-5565
ISSN (electronic): 1873-6815
Publisher: Elsevier Inc.
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