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Platelet-derived chemokines in inflammation and atherosclerosis

Lookup NU author(s): Professor Konstantinos Stellos


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© 2017. Platelets are inflammatory a nuclear cells with a well-established role in the development and manifestation of atherosclerosis. Activated platelets secrete a plethora of chemokines including CXCL4 or platelet factor 4 (PF4), CCL5, CXCL12 or stromal cell derived factor-1α (SDF-1α), CXCL16 and others, which initiate or promote local inflammatory processes at sites of vascular injury. These processes are mainly mediated by the recruitment of circulating haematopoietic stem cells, neutrophils, monocytes or lymphocytes on vascular wall. Under acute ischemic conditions platelet-derived chemokines may promote the mobilization of bone marrow-derived progenitor cells and their homing at lesion sites. This review focuses on the role of platelet-derived chemokines in inflammation and atherosclerosis. Further, we discuss the clinical value of plasma levels of chemokines in the prognosis of atherosclerotic heart disease.

Publication metadata

Author(s): Bakogiannis C, Sachse M, Stamatelopoulos K, Stellos K

Publication type: Article

Publication status: Published

Journal: Cytokine

Year: 2017

Volume: 122

Print publication date: 01/10/2019

Online publication date: 01/12/2017

Acceptance date: 11/09/2017

ISSN (print): 1043-4666

ISSN (electronic): 1096-0023

Publisher: Elsevier


DOI: 10.1016/j.cyto.2017.09.013


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