Lookup NU author(s): Professor Konstantinos Stellos
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© 2017. Platelets are inflammatory a nuclear cells with a well-established role in the development and manifestation of atherosclerosis. Activated platelets secrete a plethora of chemokines including CXCL4 or platelet factor 4 (PF4), CCL5, CXCL12 or stromal cell derived factor-1α (SDF-1α), CXCL16 and others, which initiate or promote local inflammatory processes at sites of vascular injury. These processes are mainly mediated by the recruitment of circulating haematopoietic stem cells, neutrophils, monocytes or lymphocytes on vascular wall. Under acute ischemic conditions platelet-derived chemokines may promote the mobilization of bone marrow-derived progenitor cells and their homing at lesion sites. This review focuses on the role of platelet-derived chemokines in inflammation and atherosclerosis. Further, we discuss the clinical value of plasma levels of chemokines in the prognosis of atherosclerotic heart disease.
Author(s): Bakogiannis C, Sachse M, Stamatelopoulos K, Stellos K
Publication type: Article
Publication status: Published
Online publication date: 01/12/2017
Acceptance date: 11/09/2017
ISSN (print): 1043-4666
ISSN (electronic): 1096-0023
Publisher: Academic Press
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