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Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease

Lookup NU author(s): Professor Konstantinos Stellos

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Abstract

© 2015 The Alzheimer's Association.Background Calpain has been associated with the pathophysiology of Alzheimer's disease (AD) and with apoptotic neuronal cell death leading to microparticles (MPs) formation. Methods A total of 64 patients with AD and 52 age- and gender-matched cognitively healthy elderly controls were included in the study. We measured calpain activity and levels of MPs, amyloid beta (Aβ1-42), h-tau, and p-tau181. Results AD patients showed significantly increased calpain activity and higher levels of MPs in cerebrospinal fluid (CSF) and significantly decreased calpain activity and lower levels of MPs in serum and plasma compared with healthy controls. Combined assessment of calpain activity and Aβ1-42 levels in CSF improved diagnostic accuracy as compared with singular or combined traditional CSF biomarkers of AD. Conclusions This is the first study showing increased calpain activity and microparticle levels in CSF of AD patients. Calpain activity could represent a novel diagnostic and prognostic biomarker and promising treatment target for AD.


Publication metadata

Author(s): Laske C, Stellos K, Kempter I, Stransky E, Maetzler W, Fleming I, Randriamboavonjy V

Publication type: Article

Publication status: Published

Journal: Alzheimer's and Dementia

Year: 2015

Volume: 11

Issue: 5

Pages: 465-474

Online publication date: 04/09/2014

Acceptance date: 04/09/2014

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.jalz.2014.06.003

DOI: 10.1016/j.jalz.2014.06.003

PubMed id: 25200336


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