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Lookup NU author(s): Professor Konstantinos StellosORCiD
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Background: Increasing evidence supports the role of cardiovascular risk factors in the development of Alzheimer's disease (AD). Objective: In the present pilot study, we investigated plasma concentrations of myeloperoxidase (MPO) and its possible association with plasma amyloid-β (Aβ) 1-42/1-40 ratio in AD patients and elderly healthy controls. Methods: The study sample included 28 AD patients and 27 elderly individuals with a normal cognitive status as a control group. The Mini-Mental Status Examination was used to determine the global cognition. MPO, Aβ1-40, and Aβ1-42 plasma concentrations were measured by enzyme linked immunoabsorbent assays. Results: AD patients showed significantly higher plasma concentrations of MPO in comparison to healthy elderly controls (AD versus healthy elderly controls (mean ± SD): 132.8 ± 114.8 ng/mL versus 55.0 ± 42.6 ng/mL; p = 0.002). MPO plasma concentrations showed a significant positive correlation in the whole sample with the presence of AD (ρ = 0.428, p < 0.001) and its stage (ρ = 0.331; p = 0.013) as well as with plasma concentrations of Aβ1-42 (ρ = 0.406; p = 0.004) and Aβ1-42/1-40 ratio (ρ = 0.354; p = 0.013). In a binary logistic regression model, plasma MPO concentrations were independently associated with the presence of AD (p = 0.014). Conclusion: AD patients showed significantly increased plasma levels of MPO, which could be an important molecular link between atherosclerosis and AD. Further studies should evaluate whether MPO may also be a useful biomarker and potential new treatment target in AD. © 2014-IOS Press and the authors. All rights reserved.
Author(s): Tzikas S, Schlak D, Sopova K, Gatsiou A, Stakos D, Stamatelopoulos K, Stellos K, Laske C
Publication type: Article
Publication status: Published
Journal: Journal of Alzheimer's Disease
Year: 2014
Volume: 39
Issue: 3
Pages: 557-564
Online publication date: 07/02/2014
Acceptance date: 29/09/2013
ISSN (print): 1387-2877
ISSN (electronic): 1875-8908
Publisher: IOS Press
URL: https://doi.org/10.3233/JAD-131469
DOI: 10.3233/JAD-131469
PubMed id: 24217274
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