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Combination of high on-treatment platelet aggregation and low deaggregation better predicts long-term cardiovascular events in PCI patients under dual antiplatelet therapy

Lookup NU author(s): Professor Konstantinos StellosORCiD

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Abstract

High on-treatment platelet reactivity is associated with short-term major cardiovascular (CV) events in patients undergoing percutaneous coronary intervention (PCI). Maximum and final aggregation assessed by light transmission aggregometry (LTA) have both been used to predict short-term outcome after PCI, however their long-term prognostic impact remains controversial. There is currently no information regarding the prognostic role of deaggregation and its added value in combination with established aggregation parameters. About 1279 patients with symptomatic coronary artery disease (CAD) undergoing PCI were enrolled in this monocentric study. On-treatment platelet aggregation under clopidogrel maintenance therapy, as well as deaggregation was determined by maximum and final aggregation (5min after adding of the agonist). Deaggregation was defined as slope of the tangent between Aggmax +0.5min. Primary endpoints were the composite of myocardial infarction, stroke, and CV death or stent thrombosis according to the ARC criteria. Low deaggregation, defined as values in the lowest tertile (<1.5), was more frequent in patients with acute coronary syndromes (ACS) compared to patients with stable angina pectoris (SAP), ACS: 29.6% vs. SAP: 22.0%, p=0.001. The combination of high on-treatment platelet reactivity, defined by the upper tertile of Aggmax and low deaggregation, was associated with significantly increased risk for combined long-term CV events. The combination of low deaggregation and high on-treatment platelet reactivity is associated with higher risk for recurrent events in patients with CAD undergoing PCI. Thus, deaggregation might be a more sensitive parameter providing added value in terms of risk prediction for long-term recurrent CV events in relation with established aggregation parameters. © 2014 Informa UK Ltd.


Publication metadata

Author(s): Muller KAL, Karathanos A, Tavlaki E, Stimpfle F, Meissner M, Bigalke B, Stellos K, Schwab M, Schaeffeler E, Muller II, Gawaz M, Geisler T

Publication type: Article

Publication status: Published

Journal: Platelets

Year: 2014

Volume: 25

Issue: 6

Pages: 439-446

Print publication date: 01/02/2014

Online publication date: 08/10/2013

Acceptance date: 25/07/2013

ISSN (print): 0953-7104

ISSN (electronic): 1369-1635

Publisher: Taylor & Francis

URL: https://doi.org/10.3109/09537104.2013.829914

DOI: 10.3109/09537104.2013.829914

PubMed id: 24102318


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