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Lookup NU author(s): Dr Shahriar Khateri, Professor Mahdi Balali-Mood, Professor Peter Blain, Emeritus Professor Faith Williams, Dr Paul Jowsey
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2017 Elsevier B.V. Delayed effects of sulfur mustard (SM) exposure on the levels of five important damage/repair proteins were investigated in 40 SM-exposed veterans of Iran-Iraq war and 35 unexposed controls. A major DNA damage biomarker protein – phosphorylated H2AX – along with four DNA repair proteins in cell response to the genome damage MRE11, NBS1, RAD51, and XPA were evaluated in blood lymphocytes from the veterans and controls using western blotting. Mean levels of XPA, MRE11, RAD51 and NBS1 were lower in SM-exposed patients and the decrease in NBS1 was significant. Even though the raised level of phosphor-H2AX in SM-poisoned group compared to the controls was not significant it was consistent with DNA damage findings confirming the severity of damage to the DNA after exposure to SM. There were correlations between the values of RAD51 and NBS1 proteins as well as XPA and MRE11 proteins. More than two decades after exposure to SM, there is still evidences of DNA damage as well as impaired repair mechanisms in cells of exposed individuals. Such disorders in cellular level may contribute to long term health problems of the SM veterans.
Author(s): Khateri S, Balali-Mood M, Blain P, Williams F, Jowsey P, Soroush MR, Behravan E, Sadeghi M
Publication type: Article
Publication status: Published
Journal: Toxicology Letters
Year: 2018
Volume: 293
Pages: 67-72
Print publication date: 01/09/2018
Online publication date: 05/12/2017
Acceptance date: 03/12/2017
Date deposited: 02/07/2018
ISSN (print): 0378-4274
ISSN (electronic): 1879-3169
Publisher: Elsevier Ireland Ltd
URL: https://doi.org/10.1016/j.toxlet.2017.12.001
DOI: 10.1016/j.toxlet.2017.12.001
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