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Roles of mitochondrial DNA mutations in stem cell ageing

Lookup NU author(s): Tianhong Su, Professor Doug Turnbull, Dr Laura Greaves

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Mitochondrial DNA (mtDNA) mutations accumulate in somatic stem cells during ageing and cause mitochondrial dysfunction. In this review, we summarize the studies that link mtDNA mutations to stem cell ageing. We discuss the age-related behaviours of the somatic mtDNA mutations in stem cell populations and how they potentially contribute to stem cell ageing by altering mitochondrial properties in humans and in mtDNA-mutator mice. We also draw attention to the diverse fates of the mtDNA mutations with different origins during ageing, with potential selective pressures on the germline inherited but not the somatic mtDNA mutations.


Publication metadata

Author(s): Su T, Turnbull DM, Greaves LC

Publication type: Review

Publication status: Published

Journal: Genes

Year: 2018

Volume: 9

Issue: 4

Online publication date: 27/03/2018

Acceptance date: 26/03/2018

ISSN (electronic): 2073-4425

Publisher: MDPI AG

URL: https://doi.org/10.3390/genes9040182

DOI: 10.3390/genes9040182


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