Lookup NU author(s): Dr Lucy Walker
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2018 Kurioka, Cosgrove, Simoni, van Wilgenburg, Geremia, Björkander, Sverremark-Ekström, Thurnheer, Günthard, Khanna, The Swiss HIV Cohort Study, Oxford IBD Cohort Investigators, Walker, Arancibia-Cárcamo, Newell, Willberg and Klenerman.CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells.
Author(s): Kurioka A, Cosgrove C, Simoni Y, van Wilgenburg B, Geremia A, Bjorkander S, Sverremark-Ekstrom E, Thurnheer C, Gunthard HF, Khanna N, The Swiss HIV Cohort Study, Oxford IBD Cohort Investigators, Walker LJ, Arancibia-Carcamo CV, Newell EW, Willberg CB, Klenerman P
Publication type: Article
Publication status: Published
Journal: Frontiers in Immunology
Online publication date: 09/04/2018
Acceptance date: 23/02/2018
Date deposited: 06/06/2018
ISSN (electronic): 1664-3224
Publisher: Frontiers Research Foundation
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