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Pharmacogenetics of Adverse Drug Reactions

Lookup NU author(s): Professor Ann Daly

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Abstract

© 2018 Elsevier Inc. Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Genetic factors predispose to many ADRs, affecting susceptibility to both type A and type B reactions. The overall contribution of genetics will vary according to drug and ADR, and should be considered when attempting to predict and prevent ADRs. Genetic risk factors are considered in detail for a number of type A ADRs, especially those relating to warfarin and thiopurines, and type B ADRs affecting skin, the liver, and the heart. As the availability of whole genome sequencing increases, it is likely that prospective genotype for particular ADRs prior to drug prescription will become more common in the future. Current examples of genetic testing to prevent ADRs which have already been implemented and future prospects for developments in the field are discussed in detail.


Publication metadata

Author(s): Osanlou O, Pirmohamed M, Daly AK

Editor(s): Kim Brøsen and Per Damkier

Publication type: Book Chapter

Publication status: Published

Book Title: Pharmacogenetics

Year: 2018

Volume: 83

Pages: 155-190

Online publication date: 26/05/2018

Acceptance date: 02/04/2018

Series Title: Advances in Pharmacology

Publisher: Academic Press Inc.

URL: https://doi.org/10.1016/bs.apha.2018.03.002

DOI: 10.1016/bs.apha.2018.03.002

Library holdings: Search Newcastle University Library for this item

ISBN: 9780128133811


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