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3D bioprinting of a corneal stroma equivalent

Lookup NU author(s): Abi Isaacson, Dr Steve Swioklo, Professor Che Connon

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2018 Elsevier Ltd Corneal transplantation constitutes one of the leading treatments for severe cases of loss of corneal function. Due to its limitations, a concerted effort has been made by tissue engineers to produce functional, synthetic corneal prostheses as an alternative recourse. However, successful translation of these therapies into the clinic has not yet been accomplished. 3D bioprinting is an emerging technology that can be harnessed for the fabrication of biological tissue for clinical applications. We applied this to the area of corneal tissue engineering in order to fabricate corneal structures that resembled the structure of the native human corneal stroma using an existing 3D digital human corneal model and a suitable support structure. These were 3D bioprinted from an in-house collagen-based bio-ink containing encapsulated corneal keratocytes. Keratocytes exhibited high cell viability both at day 1 post-printing (>90%) and at day 7 (83%). We established 3D bio-printing to be a feasible method by which artificial corneal structures can be engineered.


Publication metadata

Author(s): Isaacson A, Swioklo S, Connon CJ

Publication type: Article

Publication status: Published

Journal: Experimental Eye Research

Year: 2018

Volume: 173

Pages: 188-193

Print publication date: 01/08/2018

Online publication date: 30/05/2018

Acceptance date: 12/05/2018

Date deposited: 12/06/2018

ISSN (print): 0014-4835

ISSN (electronic): 1096-0007

Publisher: Academic Press

URL: https://doi.org/10.1016/j.exer.2018.05.010

DOI: 10.1016/j.exer.2018.05.010


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