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Lookup NU author(s): Professor David BrooksORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2018, The Author(s). Introduction: The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. Methods: For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (VT) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) VT images using three shortened datasets, using the original parent plasma input functions (ppIFs). Results: Correlations with the original ppIF-derived 90-min VTs increased for later interval SUVs (maximal ρ = 0.78; 80–90 min). They were strong for PBIF-derived VTs (ρ = 0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80-min original ppIF-derived VTs (ρ = 0.97–1.00), which suffered regionally variant negative bias. Conclusions: Where arterial blood sampling is available, reduction of scan duration to 60 min is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived VTs.
Author(s): McGinnity CJ, Riano Barros DA, Trigg W, Brooks DJ, Hinz R, Duncan JS, Koepp MJ, Hammers A
Publication type: Article
Publication status: Published
Journal: EJNMMI Research
Year: 2018
Volume: 8
Online publication date: 11/06/2018
Acceptance date: 08/05/2018
Date deposited: 25/06/2018
ISSN (electronic): 2191-219X
Publisher: Springer Verlag
URL: https://doi.org/10.1186/s13550-018-0396-2
DOI: 10.1186/s13550-018-0396-2
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