Lookup NU author(s): Dr Peter Vegh,
Professor Muzlifah Haniffa
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Application of single-cell genomics technologies has revolutionized our approach to study the immune system. Unravelling the functional diversity of immune cells and their coordinated response is key to understanding immunity. Single-cell transcriptomics technologies provide high-dimensional assessment of the transcriptional states of immune cells and have been successfully applied to discover new immune cell types, reveal haematopoietic lineages, identify gene modules dictating immune responses and investigate lymphocyte antigen receptor diversity. In this review, we discuss the impact and applications of single-cell RNA sequencing technologies in immunology.
Author(s): Vegh P, Haniffa M
Publication type: Article
Publication status: Published
Journal: Briefings in Functional Genomics
Online publication date: 14/03/2018
Acceptance date: 14/03/2018
ISSN (print): 2041-2649
ISSN (electronic): 2041-2657
Publisher: Oxford University Press
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