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Lookup NU author(s): Professor David BrooksORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. AD pathology is characterized by abnormal aggregation of the proteins amyloid-b (Ab) and hyper-phosphorylated tau. No effective disease modifying therapies are currently available. A short-duration intervention with 40 Hz light flicker has been shown to reduce brain Ab load in transgenic mice. We aimed to test the effect of a similar short-duration 40 Hz light flicker regime in human AD patients. We utilized a Light Emitting Diode (LED) light bulb with a 40 Hz flicker. Six Ab positive patients, received 10 days of light therapy, 2 hours of daily exposure, and underwent a post-intervention PiB PET on day 11. After 10 days of light therapy, no significant decrease of PiB SUVR values were detected in any volumes of interest tested (primary visual cortex, visual association cortex, lateral parietal cortex, precuneus, posterior cingulate) or in the total motor cortex, and longer treatments may be necessary to induce amyloid removal in humans.
Author(s): Ismail R, Hansen AK, Parbo P, Brændgaard H, Gottrup H, Brooks DJ, Borghammer P
Publication type: Article
Publication status: Published
Journal: International Journal of Alzheimer's Disease
Year: 2018
Volume: 2018
Online publication date: 30/07/2018
Acceptance date: 25/06/2018
Date deposited: 28/06/2018
ISSN (print): 2090-8024
ISSN (electronic): 2090-0252
Publisher: Hindawi Publishing
URL: https://doi.org/10.1155/2018/6852303
DOI: 10.1155/2018/6852303
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