Lookup NU author(s): Dr Chris Smart,
Professor Hamish McAllister-Williams,
Dr David Cousins
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Dopamine receptor antagonists can be effective in psychotic depression but response is not assured. Visual hallucinations may arise from a dysregulation of brain cholinergic systems and acetylcholinesterase inhibitors (AChEIs) can treat such hallucinations in dementia with Lewy bodies (DLB). AChEIs have been used in schizophrenia with some success but their efficacy and tolerability in psychotic depression is unclear. This striking case illustrates AChEIs specifically targeting multimodal hallucinations in treatment-resistant depression. To our knowledge it is the first case report to do so. It highlights the value of delineating psychopathology when considering novel interventions. This case also shows the idiosyncratic nature of side effects and the importance of pursuing different drugs within class.
Author(s): Smart C, McAllister-Williams RH, Cousins DA
Publication type: Article
Publication status: Published
Journal: Therapeutic Advances in Psychopharmacology
Print publication date: 01/01/2018
Online publication date: 10/07/2018
Acceptance date: 08/06/2017
ISSN (print): 2045-1253
ISSN (electronic): 2045-1261
Publisher: Sage Publications Ltd
Altmetrics provided by Altmetric