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Pulsatile release from a flat self-oscillating chitosan macrogel

Lookup NU author(s): Dr Anna Isakova, Dr Katarina Novakovic

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Royal Society of Chemistry, 2018.

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Abstract

Coupling oscillatory chemical reactions to smart materials which can respond to external stimuli has long been considered an answer to the long-standing issue of pulsatile drug delivery. Although a number of coupled architectures exist, there are no systems reporting pH-controlled pulsed drug release based on chemical oscillators. In this paper, we report for the first time a proof-of-concept self-oscillatory chitosan macrogel, employing the palladium-catalysed oxidative carbonylation reaction as the driving force of its oscillations. The reported hydrogel is composed of highly biocompatible components and a novel imine-functionalised chitosan-palladium catalyst with zero leaching rates. This macrogel was shown to rhythmically release not only the products of the reaction, but also fluorescein, which is used as an FDA-approved model drug. The step-wise release pattern corresponded to the step-wise dynamics of pH decrease in methanol:water, while in pure methanol, the changes in pH had an oscillatory mode, accompanied by mirrored oscillations in fluorescein concentration. This proof-of-concept system significantly expands the horizons of pulsatile delivery materials for future research.


Publication metadata

Author(s): Isakova A, Novakovic K

Publication type: Article

Publication status: Published

Journal: Journal of Materials Chemistry B

Year: 2018

Issue: 30

Pages: 5003-5010

Print publication date: 14/08/2018

Online publication date: 20/07/2018

Acceptance date: 14/07/2018

Date deposited: 16/07/2018

ISSN (print): 2050-750X

ISSN (electronic): 2050-7518

Publisher: Royal Society of Chemistry

URL: https://doi.org/10.1039/C8TB00781K

DOI: 10.1039/C8TB00781K

Data Source Location: http://dx.doi.org/10.17634/153345-2


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