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Downregulation of miRNA-29, -23 and -21 in urine of Duchenne muscular dystrophy patients

Lookup NU author(s): Lauren Phillips, Professor Volker Straub

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Abstract

© 2018 Future Medicine Ltd. Aim: To study the signature of 87 urinary miRNAs in Duchenne muscular dystrophy (DMD) patients, select the most dysregulated and determine statistically significant differences in their expression between controls, ambulant (A) and nonambulant (NA) DMD patients, and patients on different corticosteroid regimens. Patients/materials & methods: Urine was collected from control (n = 20), A (n = 31) and NA (n = 23) DMD patients. miRNA expression was measured by reverse transcription-quantitative PCR. Results: miR-29c-3p was significantly downregulated in A DMD patients while miR-23b-3p and miR-21-5p were significantly downregulated in NA DMD patients compared with age-matched controls. Conclusion: miR-29c-3p, miR-23b-3p and miR-21-5p are promising novel noninvasive biomarkers for DMD, and miR-29c-3p levels are differentially affected by different steroid regimens, supporting the antifibrotic effect of steroid therapy.


Publication metadata

Author(s): Catapano F, Domingos J, Perry M, Ricotti V, Phillips L, Servais L, Seferian A, Groot ID, Krom YD, Niks EH, Verschuuren JJGM, Straub V, Voit T, Morgan J, Muntoni F

Publication type: Article

Publication status: Published

Journal: Epigenomics

Year: 2018

Volume: 10

Issue: 7

Pages: 875-890

Online publication date: 22/03/2018

Acceptance date: 02/04/2018

ISSN (print): 1750-1911

ISSN (electronic): 1750-192X

Publisher: Future Medicine Ltd.

URL: https://doi.org/10.2217/epi-2018-0022

DOI: 10.2217/epi-2018-0022


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