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Scaling-down antibody radiolabeling reactions with zirconium-89

Lookup NU author(s): Dr James Knight

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Abstract

© The Royal Society of Chemistry 2016. The most widely cited procedures for radiolabeling antibodies with zirconium-89 for immuno-PET require multi-milligram amounts of antibody which can be cost-prohibitive, particularly during the research and development process. We therefore sought to develop a reliable 89Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale.


Publication metadata

Author(s): Knight JC, Paisey SJ, Dabkowski AM, Marculescu C, Williams AS, Marshall C, Cornelissen B

Publication type: Article

Publication status: Published

Journal: Dalton Transactions

Year: 2016

Volume: 45

Issue: 15

Pages: 6343-6347

Print publication date: 21/04/2016

Online publication date: 11/03/2016

Acceptance date: 07/03/2016

ISSN (print): 1477-9226

ISSN (electronic): 1477-9234

Publisher: Royal Society of Chemistry

URL: https://doi.org/10.1039/c5dt04774a

DOI: 10.1039/c5dt04774a

PubMed id: 26986633


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