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Continuous Positive Airway Pressure effect on visual acuity in patients with type 2 diabetes and Obstructive Sleep Apnoea: a multicentre randomised controlled trial

Lookup NU author(s): Dr Sophie West, Dr Ben Prudon, Joan Hughes

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by European Respiratory Society, 2018.

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Abstract

Objective: We sought to establish whether CPAP for OSA in people with type 2 diabetes and diabetic macular oedema (DME) improved visual acuity.Methods: We randomly assigned 131 eligible patients aged 30–85 years from 23 UK centres with significant DME causing visual impairment (LogMAR letters identified, = 39–= 78, score 0.92–0.14) plus severe OSA on screening to either: usual ophthalmology care (n=67) or usual ophthalmology care plus CPAP (n=64) for 12 months.Results: Mean age of participants was 64 years, 73% male, mean BMI 35.0 kg·m-2. Mean 4% oxygen desaturation index was 36/hour. There was no significant difference in the visual acuity at twelve months between the CPAP group and the control group, mean LogMAR (95%CI) 0.33 (0.29, 0.37) versus 0.31 (0.27, 0.35), p=0.39, and no significant correlation between change in LogMAR and average CPAP use. The median daily CPAP use (sd, range) was 3.33 (2.25, 0–7.93) hours at three months, 3.19 (2.54, 0–8.07) hours at six months and 3.21 (2.7, 0–7.98) hours at twelve months.Conclusion: CPAP therapy for OSA did not improve visual acuity in people with type 2 iabetes and diabetic macular oedema compared to usual care alone over 12 months.


Publication metadata

Author(s): West SD, Prudon B, Hughes J, Gupta R, Mohammed SB, Gerry S, Stradling JR

Publication type: Article

Publication status: Published

Journal: European Respiratory Journal

Year: 2018

Volume: 52

Issue: 4

Print publication date: 01/10/2018

Online publication date: 30/08/2018

Acceptance date: 30/08/2018

Date deposited: 12/09/2018

ISSN (print): 0903-1936

ISSN (electronic): 1399-3003

Publisher: European Respiratory Society

URL: https://doi.org/10.1183/13993003.01177-2018

DOI: 10.1183/13993003.01177-2018

PubMed id: 30166323


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