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The utility and application of electrophysiological methods in the study of visual hallucinations

Lookup NU author(s): Kat Da Silva Morgan, Dr Greg Elder, Daniel Collerton, Professor John-Paul Taylor

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Abstract

© 2018 International Federation of Clinical Neurophysiology Visual hallucinations (VH) are a common symptom in multiple clinical and non-clinical populations. Although structural and functional neuroimaging has informed the understanding of VH, temporal resolution is limited. Electrophysiological techniques provide a complementary perspective on dynamic and temporal aspects of neural functioning, offering greater insight into the mechanisms underlying their formation. In this review we examine and critically evaluate the emerging evidence base utilising electrophysiological approaches in the study of VH. Overall, increased visual system excitability, dysfunctional visual processing and network connectivity, and cholinergic dysfunction have been consistently observed in VH-prone pathologies. However, a major limitation is in the lack of robust experimental studies and the reliance on single case reports. We conclude that electrophysiology provides tentative evidence for the contribution of bottom-up, top-down, and network dysfunction in the aetiology of VH, supporting several existing VH models. Furthermore, we discuss how electrophysiology has been directly utilised in specific clinical interventions for VH. Further exploration utilising electrophysiology in combination with, for example, neuroimaging will help better understand VH aetiology while aiding in the development of novel therapeutic interventions for this difficult to treat symptom.


Publication metadata

Author(s): daSilva Morgan K, Elder GJ, ffytche DH, Collerton D, Taylor J-P

Publication type: Review

Publication status: Published

Journal: Clinical Neurophysiology

Year: 2018

Volume: 129

Issue: 11

Pages: 2361-2371

Print publication date: 01/11/2018

Online publication date: 06/09/2018

Acceptance date: 21/08/2018

ISSN (print): 1388-2457

ISSN (electronic): 1872-8952

Publisher: Elsevier Ireland Ltd

URL: https://doi.org/10.1016/j.clinph.2018.08.019

DOI: 10.1016/j.clinph.2018.08.019


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