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Modelling the role of redox-related mechanisms in musculoskeletal ageing

Lookup NU author(s): Alvaro Martinez Guimera, Dr Daryl Shanley, Dr Carole Proctor

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Abstract

© 2018 The decline in the musculoskeletal system with age is driven at the cellular level by random molecular damage. Cells possess mechanisms to repair or remove damage and many of the pathways involved in this response are regulated by redox signals. However, with ageing there is an increase in oxidative stress which can lead to chronic inflammation and disruption of redox signalling pathways. The complexity of the processes involved has led to the use of computational modelling to help increase our understanding of the system, test hypotheses and make testable predictions. This paper will give a brief background of the biological systems that have been modelled, an introduction to computational modelling, a review of models that involve redox-related mechanisms that are applicable to musculoskeletal ageing, and finally a discussion of the future potential for modelling in this field.

Publication metadata

Author(s): Martinez Guimera A, Shanley DP, Proctor CJ

Publication type: Article

Publication status: Published

Journal: Free Radical Biology and Medicine

Year: 2019

Volume: 132

Pages: 11-18

Print publication date: 20/02/2019

Online publication date: 13/09/2018

Acceptance date: 12/09/2018

ISSN (print): 0891-5849

ISSN (electronic): 1873-4596

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.freeradbiomed.2018.09.013

DOI: 10.1016/j.freeradbiomed.2018.09.013

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