Lookup NU author(s): Daniel Wood,
Professor Jane Endicott
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2018 The Authors. Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism and cell differentiation. The cyclins, though originally characterized as CDK partners, also have CDK-independent roles that include the regulation of DNA damage repair and transcriptional programmes that direct cell differentiation, apoptosis and metabolic flux. This review compares the structures of the members of the CDK and cyclin families determined by X-ray crystallography, and considers what mechanistic insights they provide to guide functional studies and distinguish CDK- and cyclin-specific activities. Aberrant CDK activity is a hallmark of a number of diseases, and structural studies can provide important insights to identify novel routes to therapy.
Author(s): Wood DJ, Endicott JA
Publication type: Review
Publication status: Published
Journal: Open Biology
Online publication date: 05/09/2018
Acceptance date: 10/08/2018
ISSN (electronic): 2046-2441
Publisher: Royal Society Publishing
PubMed id: 30185601