Lookup NU author(s): Professor Nicola Pavese
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
For patients with incurable neurodegenerative disorders such as Huntington’s (HD) and Parkinson’s disease, cell transplantation has been explored as a potential treatment option. Here we present the first clinico-pathological study of a patient with HD in receipt of cell-suspension striatal allografts who took part in the NEST-UK multi-centre clinical transplantation trial. Using various immunohistochemical techniques, we found a discrepancy in the survival of grafted projection neurons with respect to grafted interneurons as well as a major ongoing inflammatory and immune responses to the grafted tissue with evidence of mutant huntingtin aggregates within the transplant area. Our results indicate that grafts can survive more than a decade post-transplantation but show compromised survival with inflammation and mutant protein being seen within the transplant site.
Author(s): Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, Watts C, Tai Y, Pavese N, Savage JC, Tremblay ME, Gould P, Rosser AE, Dunnett SB, Piccini P, Barker RA, Cicchetti F
Publication type: Article
Publication status: Published
Journal: Annals of Neurology
Print publication date: 01/12/2018
Online publication date: 04/10/2018
Acceptance date: 27/09/2018
Date deposited: 22/10/2018
ISSN (print): 0364-5134
ISSN (electronic): 1531-8249
Publisher: John Wiley & Sons, Inc.
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