Lookup NU author(s): Dr Anthony Watson
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Taylor and Francis, 2018.
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Emerging evidence from human intervention trials indicates health benefits of consuming blackcurrant fruit, including improvements to cognitive performance, modulation of blood flow, regulation of blood glucose and inhibition of enzymes underpinning normal cognitive function. Of particular relevance is our previous demonstration of monoamine oxidase (MAO)-A and B inhibition after the consumption of a New Zealand "Blackadder" blackcurrant juice in humans. The current study uses a double-blind, placebo-controlled, randomised cross- over design to assess the pharmacodynamics of the effects on platelet MAO-B inhibition and associated substrates, plasma prolactin levels and blood glucose levels after consumption of a single serve of "Blackadder" blackcurrant juice standardised to 500 mg polyphenols. Eight healthy male (20--35 years) participants completed the trial. Measurements were obtained at baseline 15, 30, 45, 60, 100, 120, 150, 180, 240 mins and 24 h post dose. A fast, absolute and reversible inhibition of blood platelet MAO-B (P < 0.001) and a significant but delayed reduction in plasma prolactin (P < 0.001) were observed following the consumption of "Blackadder" blackcurrant juice when compared to a placebo control. No interpretable changes in substrates of MAO or associated metabolites were seen. These data provide a clear time course of the reversible inhibition of MAO-B after the single consumption of a of New Zealand "Blackadder" blackcurrant juice standardised at 500 mg of polyphenols and, therefore, provide a therapeutic window on which to base future nutritional interventions.
Author(s): Watson AW, Scheepens A, Kennedy DO, Cooney JM, Trower TM, Haskell-Ramsay CF
Publication type: Article
Publication status: Published
Journal: Nutritional Neuroscience
Pages: Epub ahead of print
Online publication date: 05/10/2018
Acceptance date: 08/09/2018
Date deposited: 24/10/2018
ISSN (print): 1028-415X
ISSN (electronic): 1476-8305
Publisher: Taylor and Francis
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