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Imaging Markers of Progression in Parkinson's Disease

Lookup NU author(s): Professor Nicola Pavese

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Abstract

© 2018 International Parkinson and Movement Disorder Society Background: Parkinson's disease (PD) is the second-most common neurodegenerative disorder after Alzheimer's disease; however, to date, there is no approved treatment that stops or slows down disease progression. Over the past decades, neuroimaging studies, including molecular imaging and MRI are trying to provide insights into the mechanisms underlying PD. Methods: This work utilized a literature review. Results: It is now becoming clear that these imaging modalities can provide biomarkers that can objectively detect brain changes related to PD and monitor these changes as the disease progresses, and these biomarkers are required to establish a breakthrough in neuroprotective or disease-modifying therapeutics. Conclusions: Here, we provide a review of recent observations deriving from PET, single-positron emission tomography, and MRI studies exploring PD and other parkinsonian disorders.


Publication metadata

Author(s): Strafella AP, Bohnen NI, Pavese N, Vaillancourt DE, van Eimeren T, Politis M, Tessitore A, Ghadery C, Lewis S

Publication type: Article

Publication status: Published

Journal: Movement Disorders Clinical Practice

Year: 2018

Volume: 5

Issue: 6

Pages: 567-663

Print publication date: 01/11/2018

Online publication date: 15/08/2018

Acceptance date: 30/07/2018

ISSN (print): 0885-3185

ISSN (electronic): 2330-1619

Publisher: John Wiley & Sons, Inc.

URL: https://doi.org/10.1002/mdc3.12673

DOI: 10.1002/mdc3.12673


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