Lookup NU author(s): Professor Tiago Outeiro
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Alpha-synuclein (aSyn) is a key player in a group of neurodegenerative diseases commonly known as synucleinopathies. Recent findings indicate phosphorylation in several aSyn residues can modulate its aggregation and subcellular localization, thereby affecting pathological processes. However, the precise molecular mechanisms governing aSyn phosphorylation are still unclear. Recent studies investigated the role of various families of protein kinases, such as the polo-like kinases, G protein-coupled receptor kinases or casein kinases. In contrast, our understanding of the phosphatases involved in the dephosphorylation of aSyn is rather limited. Here, we exploited the unique toolbox of the yeast Saccharomyces cerevisiae in order to identify novel phosphatases capable of modulating aSyn phosphorylation, inclusion formation and toxicity of human aSyn. In summary, given the association between aSyn phosphorylation and pathology in Parkinson's disease and other synucleinopathies, modulation of this post-translational modification may constitute an attractive target for therapeutic intervention.
Author(s): Bras IC, Tenreiro S, Silva AM, Outeiro TF
Publication type: Article
Publication status: Published
Journal: FEMS Yeast Research
Print publication date: 01/12/2018
Online publication date: 01/10/2018
Acceptance date: 30/09/2018
ISSN (print): 1567-1356
ISSN (electronic): 1567-1364
Publisher: Oxford University Press
PubMed id: 30277516
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