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Regulation of phagosome functions by post-translational modifications: a new paradigm

Lookup NU author(s): Dr Paul Dean, Dr Tiaan Heunis, Professor Matthias Trost

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

Phagosomes are highly dynamic organelles formed by the uptake of particles through phagocytic innate immune cells such as macrophages. Their key roles in microbe elimination and antigen presentation make them essential for innate and adaptive immunity. However, phagosomes are also important for tissue homeostasis as even in healthy individuals billions of dead cells are phagocytosed each day. In this short review, we highlight how the use of latex beads as inert baits for phagocytosis and subsequent analysis by proteomics has changed our understanding of the phagosome. We further discuss how recent data on post-translational modifications such as phosphorylation and ubiquitylation that regulate phagosome functions and demonstrate that the phagosome is not only a ‘degradative organelle’ but also serves as a subcellular signalling platform.


Publication metadata

Author(s): Dean P, Heunis T, Härtlova A, Trost M

Publication type: Review

Publication status: Published

Journal: Current Opinion in Chemical Biology

Year: 2019

Volume: 48

Pages: 73-80

Print publication date: 01/02/2019

Online publication date: 24/11/2018

Acceptance date: 06/11/2018

ISSN (print): 1367-5931

ISSN (electronic): 1879-0402

URL: https://doi.org/10.1016/j.cbpa.2018.11.001

DOI: 10.1016/j.cbpa.2018.11.001


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