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Lookup NU author(s): Dr Arian Laurence
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© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal lamina propria, particularly in Crohn’s disease. CD161+ Treg cells had an all-trans retinoic acid (ATRA)-regulated gene signature, and CD161 expression on Treg cells was induced by ATRA, which directly regulated the CD161 gene. CD161 was co-stimulatory, and ligation with the T cell antigen receptor induced cytokines that accelerated the wound healing of intestinal epithelial cells. We identified a transcription-factor network, including BACH2, RORγt, FOSL2, AP-1 and RUNX1, that controlled expression of the wound-healing program, and found a CD161+ Treg cell signature in Crohn’s disease mucosa associated with reduced inflammation. These findings identify CD161+ Treg cells as a population involved in controlling the balance between inflammation and epithelial barrier healing in the gut.
Author(s): Povoleri GAM, Nova-Lamperti E, Scotta C, Fanelli G, Chen Y-C, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun H-W, Shih H-Y, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B
Publication type: Article
Publication status: Published
Journal: Nature Immunology
Year: 2018
Volume: 19
Pages: 1403-1414
Print publication date: 01/12/2018
Online publication date: 05/11/2018
Acceptance date: 07/09/2018
ISSN (print): 1529-2908
ISSN (electronic): 1529-2916
Publisher: Nature Publishing Group
URL: https://doi.org/10.1038/s41590-018-0230-z
DOI: 10.1038/s41590-018-0230-z
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