Lookup NU author(s): Dr Kay Mann,
Dr Laura Basterfield,
Dr Kathryn Parkinson,
Professor Ashley Adamson,
Professor Mark Pearce
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Cambridge University Press, 2019.
For re-use rights please refer to the publisher's terms and conditions.
Birth weight and early growth have been associated with later blood pressure. However, not all studies consistently find a significant reduction in blood pressure with an increase in birth weight. In addition, the relative importance of birth weight and of other lifestyle and environmental factors is often overlooked and the association is rarely studied in adolescents. We investigated early life predictors, including birth weight, of adolescent blood pressure in the Gateshead Millennium Study (GMS). The GMS is a cohort of 1029 individuals born in 1999-2000 in Gateshead in Northern England. Throughout infancy and early childhood, detailed information was collected including birth weight and measures of height and weight. Assessments of 491 returning participants at age 12 years included measures of body mass and blood pressure. Linear regression and path analysis were used to determine predictors and their relative importance on blood pressure. Birth weight was not directly associated with blood pressure at age 12. However, after adjustment for contemporaneous BMI, an inverse association of standardised birth weight on systolic blood pressure was significant. The relative importance of birth weight on later systolic blood pressure was smaller than other contemporaneous body measures (height and BMI). There was no independent association of birth weight on blood pressure seen in this adolescent population. Contemporaneous body measures have an important role to play. Lifestyle factors that influence body mass or size, such as diet and physical activity, is where interventions directed at early prevention of hypertension should be targeted.
Author(s): Mann KD, Basterfield L, Wright C, Parkinson K, Reilly JK, Reilly JJ, Adamson AJ, Pearce MS
Publication type: Article
Publication status: Published
Journal: Journal of Developmental Origins of Health and Disease
Pages: epub ahead of print
Online publication date: 09/01/2019
Acceptance date: 06/12/2018
Date deposited: 11/12/2018
ISSN (print): 2040-1744
ISSN (electronic): 2040-1752
Publisher: Cambridge University Press
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