Lookup NU author(s): Dr Gareth Parry
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© 2018 Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (α = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30–1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13–4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49–4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36–11.20). Implications: The observed MNA necessitates adherence-enhancing interventions encompassing the entire post–heart transplant medication regimen. ClinicalTrials.gov identifier: NCT01608477.
Author(s): Helmy R, Scalso de Almeida S, Denhaerynck K, Berben L, Dobbels F, Russell CL, de Aguiar Roza B, De Geest S, Crespo-Leiro MG, Cupples S, De Simone P, Groenewoud A, Kugler C, Ohler L, Van Cleemput J, Poncelet AJ, Sebbag L, Michel M, Bernard A, Doesch A, Livi U, Potena L, Brossa-Loidi V, Segovia-Cubero J, Almenar-Bonet L, Saint-Gerons CS, Mohacsi P, Horvath E, Riotto C, Parry G, Firouzi A, Kozuszko S, Haddad H, Kaan A, Fisher G, Miller T, Flattery M, Ludrosky K, Albert N, Coleman B, Trammell J, Epstein F, St Clair K, Kao A, Molina M, Canales KR, Ayoub AC, Barone F, Harkess M, Maddicks-Law J
Publication type: Article
Publication status: Published
Journal: Clinical Therapeutics
Print publication date: 01/01/2019
Online publication date: 24/12/2018
Acceptance date: 12/11/2015
ISSN (print): 0149-2918
ISSN (electronic): 1879-114X
Publisher: Elsevier Inc.
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