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Unsupervised high-intensity interval training improves glycaemic control but not cardiovascular autonomic function in type 2 diabetes patients: A randomised controlled trial

Lookup NU author(s): Dr Sarah Cassidy, Dr Dave Houghton, Dr Kate Hallsworth, Dr Guy MacGowan, Professor Michael Trenell, Dr Djordje Jakovljevic

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© The Author(s) 2018. Background: This is the first randomised controlled trial to assess the impact of unsupervised high-intensity interval training on cardiovascular autonomic function in adults with type 2 diabetes. Methods: A total of 22 individuals with type 2 diabetes (age 60 ± 2 years, 17 males) lay in a supine position for 20 min for evaluation of cardiovascular autonomic function, which included (1) time domain measures of heart rate variability, (2) frequency domain measures of heart rate variability and blood pressure variability and (3) baroreflex receptor sensitivity. Participants were randomised into 12 weeks of high-intensity interval training (3 sessions/week) or standard care control group. Results: After 12 weeks, the between-group change in HbA1c (%) was significant (high-intensity interval training: 7.13 ± 0.31 to 6.87 ± 0.29 vs Control: 7.18 ± 0.17 to 7.36 ± 0.21, p = 0.03). There were no significant changes in measures of heart rate variability; R-R interval (ms) (high-intensity interval training: 954 ± 49 to 973 ± 53 vs Control: 920 ± 6 to 930 ± 32, p = 0.672), low frequency/high frequency (high-intensity interval training: 0.90 ± 0.21 to 0.73 ± 0.07 vs Control: 1.20 ± 0.29 to 1.00 ± 0.17, p = 0.203), or blood pressure variability; systolic blood pressure low frequency/high frequency (high-intensity interval training: 0.86 ± 0.21 to 0.73 ± 0.10 vs Control: 1.06 ± 0.26 to 0.91 ± 0.14, p = 0.169). At baseline, HbA1c was negatively correlated with baroreflex receptor sensitivity (r = –0.592, p < 0.01). Conclusion: High-intensity interval training improves glycaemic control but has limited effect on cardiovascular autonomic regulation in patients with type 2 diabetes.


Publication metadata

Author(s): Cassidy S, Vaidya V, Houghton D, Zalewski P, Seferovic JP, Hallsworth K, MacGowan GA, Trenell MI, Jakovljevic DG

Publication type: Article

Publication status: Published

Journal: Diabetes and Vascular Disease Research

Year: 2018

Volume: 16

Issue: 1

Pages: 69-76

Print publication date: 01/01/2019

Online publication date: 12/12/2018

Acceptance date: 02/04/2018

ISSN (print): 1479-1641

ISSN (electronic): 1752-8984

Publisher: SAGE Publications Ltd

URL: https://doi.org/10.1177%2F1479164118816223

DOI: 10.1177/1479164118816223


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