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Lookup NU author(s): Dr Sarah Cassidy, Dr Dave Houghton, Dr Kate HallsworthORCiD, Dr Guy MacGowanORCiD, Professor Mike TrenellORCiD, Professor Djordje JakovljevicORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2018. Background: This is the first randomised controlled trial to assess the impact of unsupervised high-intensity interval training on cardiovascular autonomic function in adults with type 2 diabetes. Methods: A total of 22 individuals with type 2 diabetes (age 60 ± 2 years, 17 males) lay in a supine position for 20 min for evaluation of cardiovascular autonomic function, which included (1) time domain measures of heart rate variability, (2) frequency domain measures of heart rate variability and blood pressure variability and (3) baroreflex receptor sensitivity. Participants were randomised into 12 weeks of high-intensity interval training (3 sessions/week) or standard care control group. Results: After 12 weeks, the between-group change in HbA1c (%) was significant (high-intensity interval training: 7.13 ± 0.31 to 6.87 ± 0.29 vs Control: 7.18 ± 0.17 to 7.36 ± 0.21, p = 0.03). There were no significant changes in measures of heart rate variability; R-R interval (ms) (high-intensity interval training: 954 ± 49 to 973 ± 53 vs Control: 920 ± 6 to 930 ± 32, p = 0.672), low frequency/high frequency (high-intensity interval training: 0.90 ± 0.21 to 0.73 ± 0.07 vs Control: 1.20 ± 0.29 to 1.00 ± 0.17, p = 0.203), or blood pressure variability; systolic blood pressure low frequency/high frequency (high-intensity interval training: 0.86 ± 0.21 to 0.73 ± 0.10 vs Control: 1.06 ± 0.26 to 0.91 ± 0.14, p = 0.169). At baseline, HbA1c was negatively correlated with baroreflex receptor sensitivity (r = –0.592, p < 0.01). Conclusion: High-intensity interval training improves glycaemic control but has limited effect on cardiovascular autonomic regulation in patients with type 2 diabetes.
Author(s): Cassidy S, Vaidya V, Houghton D, Zalewski P, Seferovic JP, Hallsworth K, MacGowan GA, Trenell MI, Jakovljevic DG
Publication type: Article
Publication status: Published
Journal: Diabetes and Vascular Disease Research
Year: 2018
Volume: 16
Issue: 1
Pages: 69-76
Print publication date: 01/01/2019
Online publication date: 12/12/2018
Acceptance date: 02/04/2018
Date deposited: 10/01/2019
ISSN (print): 1479-1641
ISSN (electronic): 1752-8984
Publisher: SAGE Publications Ltd
URL: https://doi.org/10.1177%2F1479164118816223
DOI: 10.1177/1479164118816223
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