Lookup NU author(s): Ayman Alzu'bi,
Dr Gavin Clowry
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The current model, based on rodent data, proposes that thalamocortical afferents (TCA) innervate the subplate towards theend of cortical neurogenesis. This implies that the laminar identity of cortical neurons is specified by intrinsic instructionsrather than information of thalamic origin. In order to determine whether this mechanism is conserved in the primates, weexamined the growth of thalamocortical (TCA) and corticofugal afferents in early human and monkey fetal development. Inthe human, TCA, identified by secretagogin, calbindin, and ROBO1 immunoreactivity, were observed in the internal capsuleof the ventral telencephalon as early as 7–7.5 PCW, crossing the pallial/subpallial boundary (PSB) by 8 PCW before thecalretinin immunoreactive corticofugal fibers do. Furthermore, TCA were observed to be passing through the intermediatezone and innervating the presubplate of the dorsolateral cortex, and already by 10–12 PCW TCAs were occupying much ofthe cortex. Observations at equivalent stages in the marmoset confirmed that this pattern is conserved across primates.Therefore, our results demonstrate that in primates, TCAs innervate the cortical presubplate at earlier stages thanpreviously demonstrated by acetylcholinesterase histochemistry, suggesting that pioneer thalamic afferents may contributeto early cortical circuitry that can participate in defining cortical neuron phenotypes.
Author(s): Alzu'bi A, Homann-Ludiye J, Bourne JA, Clowry GJ
Publication type: Article
Publication status: Published
Journal: Cerebral Cortex
Pages: epub ahead of print
Online publication date: 21/01/2019
Acceptance date: 29/11/2018
ISSN (print): 1047-3211
ISSN (electronic): 1460-2199
Publisher: Oxford University Press
PubMed id: 30668846
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